A.D. Gafiullina1,2, Z.A. Afanaseva1,2, Z.I. Abramova3
1Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic named after prof. M.Z. Sigal, Kazan
2Kazan State Medical Academy ― Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan
3Kazan (Volga Region) Federal University, Kazan
Gafiullina Alfiya D. ― Postgraduate student of the Department of Oncology, Radiology and Palliative Medicine of the Kazan State Medical Academy ― Branch Campus of the FSBEI FPE RMACPE MOH Russia, oncologist of the oncological department №7 of the Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic named after prof. M.Z. Sigal
29 Sibirskiy trakt, Kazan, 420029, Russian Federation, tel. +7-960-053-73-75, e-mail: gafiullina.aliya@mail.ru, ORCID ID: 0000-0002-82470161X, SPIN-code: 4985-1607
Abstract. Molecular markers are an important tool for determining poor outcome in ovarian cancer. This type of cancer has the highest mortality rate among gynecological cancers, associated with late diagnosis. The study showed that the prognosis of the disease is influenced not only by the stage and extent of the tumor; the biology of the tumor, in particular the state of autophagy and apoptosis, is of great importance. Proteins of autophagy Lc3b1, Lc3b2, Beclin-1 and apoptosis Bcl-2, Casp-3 in ovarian tissue were determined by Western blotting. Two proteins, Bcl-2 and Lc3b1, were identified as molecular markers that turned out to be indicators of disease aggressiveness or prognostic factors in ovarian cancer.
Key words: autophagy, apoptosis, ovarian cancer, proteins Bсl-2, Lc3b1, Lc3b2, Casp-3, Beclin-1.