K.А. Patenko1, Z.А. Afanasyeva2, N.V. Ziganshina1
1Kamchatka Regional Oncology Dispensary, Petropavlovsk-Kamchatsky2Kazan State Medical Academy ― Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan
Patenko Kirill A. ― oncologist, head of the day hospital of the Kamchatka Regional Oncology Dispensary
15 Lukashevskiy Str., Petropavlovsk-Kamchatsky, 683024, Russian Federation, tel. +7-911-425-41-20, e-mail: patenkokirill@gmail.com
Abstract. The gut microbiome, which consists of a large number of intestinal flora with a complex structure involved in multiple important physiological functions (digestion, metabolism, immune regulation, energy conversion, and protection of intestinal mucosal integrity), is of great scientific research importance that focuses on recent advances in understanding the relationship between the gut microbiome and cancer.
The aim of the present study was to clarify the current state of the problem of studying the importance of the gut microbiome in the process of cancer treatment. The levels of interaction between the microbiota and the tumor microenvironment and the role of probiotics, prebiotics, postbiotics, antibiotics, fecal microbiota transplantation and immune checkpoint inhibitors in the efficacy of cancer therapy were reviewed.
Key words: intestinal microbiota, immunotherapy, neoplasms, cancer, oncology, immune checkpoint inhibitors.