R.A. Gagaev1, S.S. Pirogov2, O.K. Yutsevich2, I.B. Perfilev2, P.V. Pavlov3, A.A. Mitrakov1, N.N. Volchenko2, S.V. Gamayunov1,3, A.D. Kaprin2
1Nizhniy Novgorod Regional Clinical Oncology Center, Nizhny Novgorod
2P.A. Herzen Moscow Cancer Research Institute ― branch of National Medical Research Radiology Center, Moscow
3I.M. Sechenov First Moscow State Medical University, Moscow
4A.F. Tsyba Medical Radiological Scientific Center ― branch of National Medical Research Radiology Center, Obninsk
Gagaev Roman A. ― endoscopist of the endoscopy department of Nizhniy Novgorod Regional Clinical Oncology Center
11/1 Delovaya Str., Nizhny Novgorod, 603093, Russian Federation, tel. +7-904-062-15-45, e-mail: gagaeff.roman@yandex.ru, ORCID ID: 0000-0003-1746-0583
Abstract. Signet ring cell carcinoma is a specific histological subtype of gastric adenocarcinoma. The tumor name is due to the characteristic type of malignant cells nuclei, that take the form of a ring. Such cells contain a large amount of intracellular mucin, which shifts the nucleus to the periphery creating a typical microscopic appearance. Currently, there is no single point of view, regarding the treatment strategy of such patients, as well as the prognosis of the disease. Modern endoscopic technologies allow not only to detect signet ring cell carcinoma of the stomach at an early stage, but can also be the method of choice in the radical treatment of such patients. This clinical observation aims to demonstrate the results of endoscopic diagnosis of early signet ring cell carcinoma in two patients with different treatment approaches.
Key words: upper GI endoscopy, narrow-band imaging, NBI, Dual Focus, signet ring cell carcinoma.