F.Sh. Akhmetzyanov1,2, I.A. Kamalov1,2, F.F. Akhmetzyanova1
1Kazan State Medical University, Kazan
2Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic named after professor M.Z. Sigal, Kazan
Kamalov Ilyas Aglyamovich ― Cand. of Sci. (Med.), oncologist, ultrasound diagnostics doctor of the Tatarstan Cancer Center, аssistant of the Department of Oncology, radiation diagnosis and radiotherapy of the Kazan State Medical University
29 Sibirskiy tract, Kazan, 420029, Russian Federation, tel.: +7-917-267-55-11, (843) 519-27-03, e-mail: firstname.lastname@example.org
Aim ― study of peculiarities of the course of malignant tumors with preceding and concomitant cancer-associated thrombosis thromboembolic complications.
Material and methods. 270 patients with malignant neoplasms with prior and concomitant thrombosis and thromboembolic complications were followed for one year. The patients were divided into two groups. The main group included180 patients with cancer with distant metastases, the control group included 90 patients with local forms of cancer. The groups were homogeneous.
Results. More than 1 year before cancer diagnosis, 5 patients in the main group had been diagnosed with lower extremity venous thrombosis, of whom 4 died within one year of cancer progression. Thrombosis and thromboembolic complications were diagnosed in 61 patients of the main group during one year before cancer diagnosis, of whom 35 died within one year against the background of malignant tumor progression. During cancer diagnosis, lower limb venous thrombosis was diagnosed in 9 patients in both groups (7 patients in the main group, 2 patients in the control group), 5 patients (4 in the main group, 1 in the control group) died within a year. Two patients in the main group and one patient in the control group were found to have died because of the malignant tumor progression. Pulmonary embolism against the background of malignant tumor progression was the cause of death in 2 patients of the main group. In 2 patients of the comparison group the cause of death was unclear.
Conclusion. Thrombosis, a predictor of cancer, is a sign of the increased ability of a malignant tumor to spread metastatically.
Further research is needed to determine the feasibility of more advanced treatments for malignant tumors with prior and concomitant cancer-associated thrombosis.
Key words: malignancies, thrombus formation, thrombosis, pulmonary embolism, cancer-associated thrombosis.