Abstract. Since June 1996, the Tatarstan Cancer Center (Kazan) conducted extensive diagnostic work using modern immunohistochemical, immunocytochemical and molecular cytogenetic methods based on the detection of cancer cells in a number of genes and/or specific protein molecules. The total number of tumors, we investigated using immunohistochemical method, systematically increased from 150 in 1996 to 6,250 in 2015, with each expression of tumors was evaluated from 1 to 12 (usually 4-5) and more antigens. Since 2007, genetic studies of potential targets for the treatment of breast cancer, stomach and lung are conducted. To identify the HER2 oncogene amplification 894 analyzes using chromogenic in situ hybridization (CISH) in 2007-2011 and 1392 studies with fluorescent in situ hybridization (FISH) in 2011-2016 were performed.
Such growth of advanced diagnostics requires a well-coordinated work of Oncology Center staff, ranging from administration and to technicians service. Modern morphological verification of tumors enables high-quality diagnosis and treatment of cancer patients in the Republic of Tatarstan for many years.
Key words: pathological anatomy, immunohistochemistry, molecular genetic studies, targeted therapy, FISH, HER2, EML4-ALK.
S.V. Petrov1,2, T.R. Akhmetov1,2, N.V. Balatenko2, F.M. Mazitova2, A.G. Sabirov2, M.V. Galeev2, D.O. Zagvozkina2
1Kazan State Medical University, Kazan
2Tatarstan Cancer Center, Kazan
Petrov S.V. ― Professor of general pathology (pathological anatomy) department of the Kazan State Medical University, Head of laboratory of immunohistochemical diagnosis of tumors of Pathology department of the Tatarstna Cancer Center
29 Sibirskiy Trakt, Kazan, Russian Federation, 420029, tel. (843) 519-27-60, e-mail: firstname.lastname@example.org