Abstract. One of the most significant events in the molecular pathogenesis of colorectal cancer is a mutation in the gene K-ras. Data on the prognostic significance of tumor gene mutations are contradictory and are subject to debate.
Objective ― to investigate the relationship mutations in K-ras with the clinical morphological parameters of the tumor to identify the factors influencing the course and prognosis of the disease.
The study included 120 patients with colorectal cancer who received a combination treatment.
Results. The presence of mutations in K-ras gene in colorectal cancer is more common in younger patients, females, the representatives of Russian nationality. Tumors with mutations in K-ras gene frequently metastasize to regional lymph nodes and give distant metastasis. Patients with mutation in K-ras gene have lower one-year survival.
Key words: colorectal cancer, K-ras gene.
I.G. Gataullin1, M.G. Gordiev2, R.K. Shakirov2, B.I. Gataullin1
1Kazan State Medical Academy, Kazan
2Tatarstan Cancer Center, Kazan
3Volga Region branch of N.N. Blokhin Russian Cancer Research Center, Kazan
Gataullin I.G. ― D. Med. Sc., Professor of the Department of oncology, radiology and palliative medicine in Kazan State Medical Academy
29 Sibirskiy Trakt, Kazan, Russian Federation, 420029, tel. (843) 519-26-86, e-mail: firstname.lastname@example.org