A.A. Datsyuk1, M.A. Osipov1, S.V. Gamayunov1
1Nizhny Novgorod Regional Clinical Oncology Dispensary, Nizhny Novgorod
Datsyuk A.A. – oncologist
11th oncology department, State Autonomous Healthcare Institution of the Nizhny Novgorod Region, Research Institute of Oncology and Oncology, National Oncology Clinical Hospital
Delovaya st., 11/1, Nizhny Novgorod, 603093, Russian Federation, tel.: +7-904-920-94-96, e-mail: doc70doc@yandex.ru
Abstract. Colorectal cancer (CRC) is one of the most common cancer diagnoses in the world. Adjuvant chemotherapy after radical surgery of CRC is firmly established in clinical practice, nevertheless in the elderly population this type of treatment is a subject of debate: one the one hand, due to the insufficient evidence base in terms of impact on improving recurrence-free survival (RFS) and overall survival (OS) and, on the other hand, the higher likelihood of toxicity. Aim — to analyze literature data on current methods of adjuvant drug treatment of CRC in elderly patients with stage II–III CRC after surgery.
Results. The review systematizes literature data on the efficacy of adjuvant therapy in elderly patients with stage II-III CRC after surgical treatment.
Conclusions. Based on retrospective studies, adjuvant therapy in elderly CRC patients leads to an increase in both RFS and OS. The use of comprehensive geriatric assessment in the clinic is a promising tool, as it allows more precise selection of patients for adjuvant treatment.
Key words: review, adjuvant therapy, elderly patients, comprehensive geriatric assessment, overall survival, recurrence-free survival, toxicity profile.