M.P. Salamakhin1, A.Z. Milovanova2, T.S. Dergacheva1, O.V. Leonov1, Z.Z. Mamedli3
1Clinical Oncology Center, Omsk
2Omsk state medical university, Omsk
1National Medical Research Center of Oncology named after N.N. Blokhin Ministry of Health of Russia, Moscow
Salamakhin Maxim P. — PhD (Medicine), oncologist of the surgical department No. 1 of the Clinical Oncology Dispensary
9/1 Zavertyaeva Str., Omsk, 644013, Russian Federation, tel.: +7-926-467-89-88, e-mail: salamachin@rambler.ru, SPIN-код: 6960-5653, ORCID ID: 0000-0001-9753-7960
Abstract. The aim of the study was to evaluate the initiation of systemic antitumor therapy timing factors after radical surgery for colon cancer.
Materials and methods. The retrospective study included clinical data from systemic antitumor therapy indicated patients after radical surgery for verified colon cancer. Factors influencing the timing of initiation of systemic therapy were assessed.
Results. The clinical data of 758 patients who were prescribed chemotherapy were analyzed. Treatment was started in 525 (69.3%) patients, chemotherapy was not started in 233 (30.7%) patients. The rate of initiation of systemic therapy was significantly negatively affected by surgical approach: laparotomy OR 0.812 (95% CI from 0.634 to 0.973, p = 0.029) and stoma formation OR 0.507 (95% CI from 0.364 to 0.706); and positively affected by the age of patients: under 75 years OR 1.866 (95% CI from 1.193 to 2.92, p = 0.006).
Conclusion. If no contraindications, laparoscopic access should be routinely used for colon cancer patient’s treatment.
Key words: colon cancer, laporoscopy, systemic antitumor therapy, adjuvant.