Intraarterial chemotherapy for head and neck carcinoma: a systematic review and meta-analysis

S.P. Dmitriev1,2, D.A. Chichevatov2, O.M. Seliverstova2

1Nizhny Novgorod Regional Clinical Oncological Dispensary, Nizhniy Novgorod

2Penza State University, Medical Institute, Penza

Dmitriev Sergey P. ― Head of the thirteenth Oncology department of Nizhny Novgorod Regional Clinical Oncological Dispensary; Assistant of the Department of Surgery of the Penza State University, Medical Institute

11/1 Delovaya Str., Nizhniy Novgorod, 603163, Russian Federation, tel. +7-937-448-98-84, e-mail:, Researcher ID (WOS): HOH-1143-2023

Abstract. Treatment of a squamous cell carcinoma of a head and neck still remains controversial. A problem of efficient cure is far from being resolved.

Assessment of potency of intraarterial chemotherapy is the objectives of the present paper.

Methods. We have requested and retrieved 21 original articles from the world-wide publication databases. These contributions fulfilled including criteria such as the publication date since 2000, the head and neck SCC, investigated groups characteristics (age, sex, T, N, M, stage) presented, explicit declare of treatment modalities with intraarterial chemotherapy applied, accessible information about disease-free and overall survival. Finally we yielded 21 groups from 21 publications. Individual patient data and survival estimates have been restored from authors’ Kaplan ― Meier curves.

Results. Analysis has revealed high heterogeneity (I2=76,86%; 95% CI, 53,61 – 91,12) of the «random effects» models. Employment of intraarterial chemptherapy in treatment of head and neck cancer resulted in satisfactory 5-year overall survival while absence of its significant predictors.

Conclusion. Intraarterial chemotherapy may be considered an efficient treatment modality for head and neck cancer which provides the higher level of overall survival in locally advanced tumors as well. It may be regarded as alternative to conventional regimes.

Key words: squamous cell carcinoma, head and neck, intraarterial chemotherapy.