L.Kh. Mukhamatgaleeva1,2, D.V. Pasynkov1,2, А.Yu. Zuev3, O.A. Pavlikova1,2, I.V. Klyushkin4, A.L. Fedorov2

1Oncology Dispensary of Mari El Republic, Yoshkar-Ola

2Mari State University, Yoshkar-Ola

3Clinical Hospital of Mari El Republic, Yoshkar-Ola

4Kazan State Medical University, Kazan

Mukhamatgaleeva Luiza Kh. ― Cand. of Sci. (Med.), oncologist of oncosurgical department №1 of the Oncology Dispensary of Mari El Republic

22 Osipenko Str., Yoshkar-Ola, 424037, Russian Federation, e-mail:, SPIN-code: 5659-7838, ORCID ID: 0000-0003-1933-0184


Aim ― to describe the case of malignant adenomyoepithelioma of the breast and to review the corresponding literature, as well as to identify the specific mammographic and ultrasound signs of this malignancy.

Material and methods. We report the case of breast tumor witсh histologic phenotype transformed from benign fibroadenoma to the borderline phylloid tumor and finally to the malignant adenomyoepithelioma.

Results. At final examination the malignant adenomyoepithelioma showed the multi-nodular structure. Each node represented at mammography and ultrasound (US) the solid internal structure, oval shape and smooth contour. In case of suspicious non-calcified lesion found at mammography that has the solid internal structure and round or oval shape at US it is necessary to consider the following conditions during the differential diagnosis: low-grade invasive ductal carcinoma, mucinous, medillary, clear-cells carcinomas, invasive ductal carcinoma with necrosis or hemorrhage, low-grade adenosquamose carcinoma, metaplastic carcinoma, malignant adenomyoepithelioma and papillary carcinoma, as well as the following rare benign tumors: phylloid tumor, tubular adenoma, fat necrosis, intraductal papilloma, adenoma of the nipple, papilloma-related metaplastic tumors, ductal adenoma, sclerosing adenosis, complex screrozing lesion, and hemangioma.

Conclusion. We found no specific imaging signs that allowed to identify the adenomyoepithelioma. This makes necessary to consider both benign and malignant adenomyoepithelioma during the differential diagnosis of round or oval shape solid lesion detected in mammography and/or ultrasound.

Key words: adenomyoepithelioma, breast, case report, clinical and imaging characteristics, review of the literature.