N.A. Shanazarov1, S.V. Zinchenko2, D.E. Turzhanova3, E.I. Zhapparov4, R.K. Kumisbekova4
1The Medical Centre Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, Kazakhstan2Kazan (Volga Region) Federal University, Kazan,3Astana Medical University, Nur-Sultan, Kazakhstan4Multidisciplinary Medical Center of the Akimat of Nursultan, Kazakhstan
Shanazarov Nasrulla A. ― Doct. of Sci. (Med.), Professor, Head of the Photodynamic Therapy Center, Deputy Director for Strategic Development, Science and Education of The Medical Centre Hospital of the President’s Affairs Administration of the Republic of Kazakhstan
Е495 №2 Str., Yesil district, Nur-Sultan, Kazakhstan, e-mail: nasrulla@inbox.ru
Abstract. The incidence of breast cancer is constantly growing and occupies a leading place in the structure of oncological morbidity of the female population. In terms of the frequency of metastasis to the skin, breast cancer is second only to melanoma. In women, when skin metastases are detected, breast cancer is diagnosed in 51,0-70,7% of cases. In 20% of cases, newly diagnosed breast cancer is accompanied by tumor metastases to the skin. Treatment of metastatic breast cancer is systemic (chemotherapy, hormone therapy) in combination with radiation therapy and/or with further excision of the metastatic focus. One of the effective methods of treating malignant tumors is photodynamic therapy (PDT). With PDT, tumor tissues accumulate a photosensitizer to a much greater extent than the surrounding healthy tissues. When irradiated with light, a photochemical reaction occurs in the cells of the tumor tissue, as a result of which cytotoxic agents are formed, leading to necrosis and death of the tumor.
This work shows the effectiveness of photodynamic therapy in a patient with breast cancer with multiple intradermal metastases after 3 courses of neoadjuvant polychemotherapy.
Key words: breast cancer, photodynamic therapy, fluorescence diagnostics.