M.O. Vozdvizhensky1,2, O.I. Kaganov1,2, A.L. Gorbachev1, R.M. Isargapov1
1Samara Regional Clinical Oncology Dispensary, Samara
2Samara State Medical University, Samara
Vozdvizhensky Mikhail O. ― MD, Professor of the oncology department of the Samara State Medical University; Deputy chief physician for medical work of the Samara Regional Clinical Oncology Dispensary
50 Solnechnaya Str., Samara, Russian Federation, 443031, tel. (846) 994-61-96, e-mail: VozdvijnskiyMO@samaraonko.ru, SPIN-code: 9374-1183
The aim of our study was to analyze the effect of radiation therapy on the quality of life in patients at high risk of prostate cancer after surgical treatment.
Material and methods. The study included 107 patients diagnosed with prostate cancer pT3a-bN0M0 G2-5. These are groups of patients who underwent surgical treatment with adjuvant radiation therapy (67 patients) and without it (40 patients). Such indicators of the quality of life after surgical treatment as urinary incontinence, urethral stricture, nocturia were studied. A comparison of the studied groups of patients in terms of survival rates using the Kaplan ― Meier method with their comparison using a log-rank test was carried out.
Results. Overall survival rates were statistically higher in the radiation therapy group (p=0,021). When comparing cancer-specific survival, the rates were also higher in the group with the use of radiation therapy (p=0,044). When comparing disease-free survival, no statistical difference was found (p=0,134). For all the studied indicators of quality of life in the group of patients with adjuvant radiation therapy, the frequency of their occurrence is statistically higher (p<0,05).
Conclusion. The use of the surgical method in the treatment of high-risk prostate cancer patients in combination with radiation therapy significantly improves the overall and cancer-specific survival rates (p=0,021 and p=0,044, respectively). At the same time, it was the use of radiation therapy that worsened the quality of life of patients.
Key words: prostate cancer, overall survival, disease-free survival, cancer-specific survival, the quality of life.