O.S. Mikhaylova1, I.S. Raginov1-4
1Kazan State Medicale University, Kazan
2Volga Region branch of N.N. Blokhin Russian Cancer Research Center, Kazan
3Kazan Federal University, Kazan
4Republican Clinical Hospital, Kazan
Mikhaylova Olga S. ― student of the Kazan State Medicale University
49 Butlerov St., Kazan, Russian Federation, 420012, tel. +7-937-578-68-11, e-mail: firstname.lastname@example.org
Abstract. This reviews examines the effect of ATP and adenosine, which are fundamental components of the tumor environments, were they affect tumor growth, immune cell functions and tumor-host interaction in different ways. The studies addressing chemical compounds important for studying P2 receptors and also compounds with potential for cancer treatment are analyzed. Enzymes CD39 and CD73 related with the purinergic system have also been studied. They produced adenosine which leads to suppression of antitumor immune responses. These nucleotidases are the most attractive targets in the treatment of cancer.
Key words: P2 receptors, ATP, P2 receptors agonists and antagonists, CD39, CD73, cancer.