УДК 618.11-006.67:577.15

O.I. Kit, E.M. Frantsiyants, L.S. Kozlova, E.V. Verenikina, Yu.A. Pogorelova, N.S. Chugunova, I.S. Tavaryan

Rostov Cancer Research Institute at the Ministry of Health of Russia, Rostov-on-Don

Kozlova L.S. ― Cand. Biol. Sc., Associate Professor, Senior Researcher of the Rostov Cancer Research Institute at the Ministry of Health of Russia

6314 Line Str., Rostov-on-Don, Russian Federation, 344037, tel. +7-909-427-74-71, e-mail:,


Introduction. Malignant ovarian tumors have no obvious clinical signs that distinguish them from benign ones. Study of fibrinolysis system is important to understand the biological properties of ovarian cancer; it helps to specify some theoretical aspects necessary to develop new approaches to prevent the disease spread and benign tumors malignancy.

Goal ― study of plasmin (P), plasminogen (PG), its activators (uPA and tPA), PAI-1 inhibitor in the ovarian cancer tissue at I-IV stages of development in comparison with benign tumors.

Material and methods. Operating material of 76 patients with serous cystadenocarcinoma (T1N0M0; T2N0M0; T3NxM0; T4Nx-1M0; 51,5±1,7 years), 47 patients with cystadenoma, 48,8±2,7 years, was studied using ELISA method. Morphologically unaltered tissue of the ovaries removed on the occasion of the uterine fibroid in 20 patients, 52,3±1,9 years, was used as the control. 

Results. Reduction in the PG content in all the tissues studied, increase in the free P activity with T1N0M0 and T2N0M0, PG and free P depletion with T3NxM0 and T4Nx-1M0; increase in P-α2-antiplasmin (PAP) complex in all the tissues except for T4Nx-1M0 and unaffected ovary with T1N0M0, were established. Increase in uPA-AG and uPA-act in all the tissues studied, with respect to the control; reduction in tPA-AG in all the tissues and increase in tPA-act with T2N0M0 and T3NxM0, were found. PAI-1-AG increased in all the tissues with respect to the control, with T4Nx-1M0 – twice as high as in other tumors. PAI-1-act reduced in all the tissues, except for T3NxM0.

Conclusion. Similarity of PG, PAP, uPA, tPA, PAI-1 changes in malignant and benign ovarian tumors was found. It is assumed that these components can participate in the progression of cystadenocarcinoma and cystadenoma malignancy.

Key words: cystadenoma and ovarian cystadenocarcinoma, fibrinolysis system.