Introduction. Study of the biological nature of cancer can give interesting information about process course and contribute to drug therapy development.
Goal. Study of levels of certain VEGF family growth factors in the tissue of esophageal cancer of different histogenesis, its perifocal zone and resection line tissue.
Methods. The level of VEGF-A and its receptor sVEGF-R1, VEGF-C and its receptor sVEGF-R2 in tissue samples from 39 patients (27 ― esophageal squamous cell cancer (ESCC), 12 ― esophageal adenocarcinoma (EAC)), was determined using EIA method with standard test systems. All patients had II stage of the process (G2, rTNM).
Results. VEGF-A level in ESCC tissue exceeded that in conditionally intact EAC tissue by 3.2 times, VEGF-R1 in conditionally intact ESCC tissue was 1.8 times higher than that in EAC tissue. However, VEGF-A/VEGF-R1 ratio characterizing free VEGF-A level in conditionally intact EAC tissue was 1.7 times lower. VEGF-C content in ESCC tissue was 2.7 times lower than that in EAC tissue, and VEGF-R3 level had no significant difference. Naturally, VEGF-C/VEGF-R3 ratio in ESCC tissue was 2.9 times lower than that in adenocarcinoma.
Conclusion. ESCC tissue has a higher VEGF-R3 level than in EAC tissue, whereas VEGF-C content in EAC tissue is higher. Growth factor indicators in ESCC perifocal zone do not significantly differ from the corresponding conditionally intact tissue, whereas for ECA the level of the majority of studied factors (except for EGF) is intermediate between indexes in the tumor tissue and conditionally intact tissue. In conditionally intact ESCC tissue, VEGF-A, VEGF-R1, VEGF-R3 indexes (but not VEGF-C) exceed those in the corresponding EAC tissue.
Key words: esophageal squamous cell cancer, esophageal adenocarcinoma, growth factors, tumor, perifocal zone, resection line.
O.I. Kit, E.M. Frantsiyants, E.N. Kolesnikov, N.D. Cheryarina, L.S. Kozlova, Yu.A. Pogorelova
Rostov Cancer Research Institute, Rostov-on-Don
Kozlova L.S. ― Cand. Biol. Sc., Associate Professor, Senior Researcher at Laboratory of Study of pathogenesis of malignant tumors of the Rostov Cancer Research Institute
63 14th Line Str., Rostov-on-Don, Russian Federation, 344037, tel. +7-909-427-74-71, e-mail: firstname.lastname@example.org