Aim of this study was to assess risk factors affecting the possibility of optimal secondary cytoreductive surgeries, as well as factors correlating with survival in patients with ovarian cancer relapse.
Material and methods. Case histories of 53 patients were analyzed retrospectively (age: 33-76 years old; median age ― 56) with the diagnosis of ovarian cancer relapse, who underwent secondary cytoreductive surgeries at the Department of Gynecological Cancers of Regional Clinical Cancer Center of Tatarstan from January 1st, 2011 till January 1st, 2012. Data were analyzed via multi-factor logistic regression analysis, the overall survival was counted via method of Kaplan ― Meier.
Results. As a result it was found out, that risk factors, affecting survival of patients with ovarian cancer relapse after secondary cytoreductive surgeries are histological grade, extent of primary cytoreductive surgery, duration and efficacy of neoadjuvant chemotherapy, and efficacy of adjuvant chemotherapy after first relapse.
Conclusion. Thorough selection of patients for secondary cytoreductive surgeries will significantly enhance the possibility of performance optimal secondary cytoreductive surgeries. On the prognosis of patients with ovarian cancer relapse after secondary cytoreductive surgeries can impact histological grade, characteristics of relapsing tumour and efficacy of chemotherapy after first relapse.
Key words: ovarian cancer relapse, secondary cytoreductive surgery, optimal cytoreduction, prognostic factors
Tatarstan Cancer Center, Kazan
Savinona A.R. ― oncologist of the oncology department №7 of the Tatarstan Cancer Center
29 Sibirskiy Trakt, Kazan, Russian Federation, 420029, tel. +7-950-313-99-99, e-mail: firstname.lastname@example.org