УДК 618.19-006.66-079.1

V.E. Gazhonova1,2, M.P. Efremova1,2, Е.A. Dorokhova3

1Joint Hospital and Polyclinic of the administration of the President of the Russian Federation, Moscow

2Central State Medical Academy of the administration of the President of the Russian Federation, Moscow

3Clinical Hospital of the administration of the President of the Russian Federation, Moscow

Efremova M.P. ― Doctor of Ultrasonic Diagnostics, surgeon of the Joint Hospital and Polyclinic of the administration of the President of the Russian Federation, postgraduate student of the Department of radiodiagnosis of the Central State Medical Academy of the administration of the President of the Russian Federation
6 Michurinsky Av., Moscow, Russian Federation, 119330, tel.: +7-965-103-87-61, +7-918-693-74-95, e-mail:

Abstract. Breast cancer is considered to be a heterogeneous group of diseases. Up to date, four breast cancer molecular subtypes are known: luminal type A, luminal type B, HER2-positive, TN subtypes. With the beginning of the active introduction the molecular classification of breast cancer into the practical health care, the researchers tried to establish a link between the visual characteristics of breast cancer, the degree of malignancy (Grade) and the molecular subtype of tumor. In our study we examined the relationship between molecular subtype, morphology, the degree of malignancy and visual characteristics of breast cancer obtained by a new method of automated whole breast ultrasonography (ABWS). In our study included 45 women (from 38 till 78 years old) with the 54 breast cancer cases. Using ABWS scanning we evaluated the phenomenon of «radiance» in the lump, because we considered this feature to be the most informative for breast cancer. We have found a statistically significant relationship between the molecular type of breast cancer and the age of patients, their menstrual function, histological type, Grade, the expression of «radiance» phenomenon, ARFI meaning.

Key words: breast cancer, automated whole breast ultrasonography, «radiance» phenomenon.


1.    Aksel' E.M. Malignant neoplasm of the breast: the state of cancer care, morbidity and mortality. Mammologiya, 2006, no. 1, pp. 9-13 (in Russ.).
2.    Gazhonova V.E., Bachurina E.M., Khlyustina E.M., Kuleshova T.N. Automatic sonotomografiya breast (3D ABVS). Part 1. Integration of the ultrasonic method in radiological imaging standards. Poliklinika. Spetsvypusk. Luchevaya diagnostika, 2014, no. 3, pp. 42-48 (in Russ.).
3.    Gazhonova V.E., Efremova M.P., Khlyustina E.M. Automatic sonotomografiya breast (Automated Breast Volume Sonography) – a new method of diagnosing cancer. Meditsinskaya vizualizatsiya, 2015, no. 5, pp. 91-95 (in Russ.). 
4.    Kaprin A.D., Starinskiy V.V., Petrov G.V. Sostoyanie onkologicheskoy pomoshchi naseleniyu Rossii v 2013 godu [Status of cancer care the population of Russia in 2013]. Moscow: FGBU “MNIOI im. P.A. Gertsena” Minzdrava Rossii, 2014. Pp. 1-235.
5.    Rozhkova N.I. Natsional'noe rukovodstvo po mammografii [National guidance on mammography]. Moscow, 2008. Pp. 110-115.
6.    Chissov V.I., Starinskiy V.V., Petrova G.V. Zlokachestvennye novoobrazovaniya v Rossii v 2012 godu (zabolevaemost' i smertnost') [Malignancies in Russia in 2012 (morbidity and mortality)]. Moscow: MNIOI im. P.A. Gertsena, 2012. 256 p.
7.    Chissova V.I. et al. Zlokachestvennye novoobrazovaniya v Rossii (Zabolevaemost' i smertnost'): stat. sbornik. MZ RF [Malignancies in Russia (morbidity and mortality): stat. collection. MoH]. Moscow: Tsentr inform. tekhn. i epidemiol. issledovaniy v oblasti onkologii, 2012. 262 p.
8.    Chang J.M., Park I.A., Lee S.H. et al. Stiffness of tumors measured by shear-wave elastography correlated with subtypes of breast cancer. Eur. Radiology, 2013, pp. 721-730.
9.    Evans E., Whelehan P., Thomson K. et al. Invasive breast cancer: relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology, 2012, 263 (2), pp. 673-677.
10.    Irshad A., Pisano E., Baker N. et al. Assessing the role of ultrasound in predicting the biological behavior of breast cancer AJR. Am. J. Roentgenol, 2013, 200, pp. 285-290.
11.    Lamb P.M., Perry N.M., Vinnicombe S.J., Wells C.A. Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast. Clin. Radiol, 2000, 55, pp. 40-44.
12.    Perou C.M., Sorlie T., Eisen M.B. et al. Molecular portraits of human breast tumours. Nature, 2000, 406 (6797), pp. 747-752.
13.    Sophia Zadelis and Nehmat Houssami Mammographic features of breast cancer in young symptomatic women. Australas Radiol, 2003, 47, pp. 4040-408.
14.    Sorlie T., Perou C.M., Tibshirani R. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA, 2001, 19 (98), pp. 10869-10874.
15.    Sorlie T., Tibshirani R., Parker J. et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. USA, 2003, 14 (100), pp. 8418-8423.
16.    Sotiriou C., Neo S.Y., McShane L.M. et al. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc. Natl. Acad. Sci. USA, 2003, 18 (100), pp. 10393-10398.
17.    Shin H.J., Kim H., Huh M.O. et al. Correlation between mammographic and sonographic findings and prognostic factors in patients with node-negative invasive breast cancer. Br. J. Radiol, 2011, 84, pp. 19-30.
18.    Taneja S., Evans A.J., Rakha E.A. et al. The mammographic correlations of a new immuno-histochemical classification of invasive cancer. Clin. Radiol, 2008, 63, pp. 1228-1235.
19.    Wang Y., Ikeda D.M., Narasimhan B. et al. Estrogen receptor-negative invasive breast cancer: imaging features of tumors with and without human epidermal growth factor receptor type 2 overexpression. Radiology, 2008, 246 (2), pp. 367-375.
20.    Breast cancer in Chinese women younger than age 40: are they different from their older counterparts? World J. Surg, 2008, Dec, 32 (12), pp. 2554-61. doi: 10.1007/s00268-008-9589-6.