O.I. Kaganov1, 2, M.V. Tkachev1, 2, A.V. Bukin2, V.I. Kolinchenko2, B.B. Dzhuraev2
1Samara Regional Clinical Oncology Dispensary, Samara
2Samara State Medical University, Samara
Bukin A.V. — 6th year student
50 Solnechnaya St., 443031 Samara, Russian Federation, e-mail: aarbukin@yandex.ru, ORCID ID: 0009-0007-0946-8047
Abstract. Surgical advances in breast cancer contribute to improving the postoperative quality of life.
The purpose — to evaluate the short- and long-term outcomes of breast-preserving surgery.
Material and methods. The study included the treatment outcomes reported for 194 patients diagnosed with breast cancer admitted to the Samara Regional Clinical Cancer Hospital between 2011 and 2020. Group 1 (p = 96) underwent conventional breast-preserving surgeries. For group 2 (p = 98), we used a modified approach named «Choosing the extent of surgery for patients diagnosed with breast cancer». This technique involved the placement of the lateral adipocutaneous flap in the axillary region, with the free edge positioned close to the nervus thoracicus longus. The analysis focused on operative time and intraoperative blood loss. We estimated the disease-free and overall survival probabilities using the Kaplan — Meier method. The patients completed the Breast-Q questionnaire prior to surgery and six months after treatment. The statistical analysis was performed using the parametric (Student’s t-test) and non-parametric (Mann — Whitney test, chi-squared test [χ2], and Fisher’s exact test) methods. The significance level was set at p < 0.05.
Results. The short-term surgical outcomes were not significantly different between the groups. The mean operative time was 76.3 ± 23.3 minutes in group 1 and 65.5 ± 18.3 minutes in group 2 (p < 0.001), with the intraoperative blood loss of 53.1 ± 26.2 ml and 49.0 ± 14.3 ml, respectively (p = 0.18). Postoperatively, persistent non-infected seroma (>14 days) was identified in 19 patients from group 1 and 7 patients from group 2 (p = 0.009).
Conclusion. The proposed method provides a significant reduction in the incidence of complications, with long-term outcomes comparable to those observed in the conventional treatment group.
Key words: breast cancer; breast-conserving surgery; surgical treatment