A.Kh. Ismagilov1, N.G. Asnina2, M.B. Vasiliev3, G.A. Azarov3, A.A. Ovsyannikov3
1Kazan State Medical Academy – Branch Campus of the FSBEI FPE RMACPE MON Russia, Kazan
2 Voronezh State University, Voronezh
3Voronezh Regional Clinical Oncology Dispensary, Voronezh
Ismagilov A.Kh. — D.Sc. (medicine), Professor of the Department of Oncology, Radiology and Palliative Care of Kazan State Medical Academy – Branch Campus of the FSBEI FPE RMACPE MON Russia 11 Mushtari St., Kazan, Russian Federation, 420012
Timely diagnosis and pre-operative statistical prognosis of regional lymph nodes lesion are of great importance to determining the prognosis and choosing the optimal treatment tactics, as well as to assessing the possibility of optimizing lymph node dissection. In this paper, a statistical analysis of clinical data and morphological factors obtained in the Oncology Department of Breast Pathology of Voronezh Regional Clinical Oncology Dispensary was conducted in the course of a comprehensive study of 223 patients. Only stages I T1N0M0 and IIa T2N0M0 were taken into account. During the study using cluster analysis it was found that the frequency of metastasis to regional lymph nodes is estimated to be more than two times lower in patients with an average age of 65 years, average Ki-67 16.52% and average tumor size of 18.2 mm than in patients with an average age of 57 years, average Ki-67 75% and average tumor size of 34 mm. There is a cluster of patients, identified by the set of signs of HER2, Er, PgR, Ki67, histological diagnosis, in which the frequency of metastasis to regional lymph nodes is significantly lower than in representatives of other clusters, identified by the same signs. Studies have shown that there is the possibility of pre-operative prediction of metastatic lesions of regional lymph nodes in patients with breast cancer not by one sign (histological or morphological), but by their totality.
Key words: breast cancer, regional lymph nodes.