Valiullin L.R.1, Idiyatov I.I.1, Mukhammadiev Rin.S.1, Egorov V.I.1, Biryulya V.V.1, Nabatov A.A.2, Raginov I.S.3-4
1Federal Center of Toxicological, Radiation and Biological Safety, Kazan
2Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan
3Volga branch of N.N. Blokhin National Medical Research Centre of Oncology, Kazan
4Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan, Kazan
Valiullin Lenar Rashitovich — PhD (biology), Head of the Sector of Tissue Technologies and Production of Medicines of Federal Center for Toxicological, Radiation and Biological Safety
2 Nauchnyy Gorodok, Kazan, Russian Federation 420074, tel. +7-950-969-84-69, e-mail: Valiullin27@mail.ru
Abstract. Currently, oncological diseases are among the most serious public health problems in the world. Oncological diseases are the main cause of death in developed countries and the second leading cause in developing countries. This work is devoted to the study of the cytostatic properties of Zearalenone and Trichothecene when exposed to cervical cancer cell lines (HeLa). It was found that Zearalenone reduced the viability of cervical cancer cells at concentration of 4,1×10-4M by 24.5%, and Trichothecene at significantly lower concentration of 4,1×10-8M reduced the viability of these cells by 42.0% as compared to the control. Based on the results, it is possible to continue research in the field of development of drugs directed against cervical cancer, which should have not only high cytotoxic effect but also increased penetrating and bioresorbable parameters, which means less negative impact on the human body.
Key words: HeLa cancer cells, Zearalenone, Trichothecene, cytotoxicity, viability, proliferative activity.