M.A. Khasanova, E.E. Khaphizova
Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan, Volga branch of Russian Cancer Research Center named after N.N. Blokhin of the Russian Academy of Medical Sciences, Kazan
Khasanova M.A. – doctor-laboratory assistant of a clinical-diagnostic laboratory of the highest qualification grade of Tatarstan Cancer Center, Kazan, Volga branch of Russian Cancer Research Center named after N.N. Blokhin of the Russian Academy of Medical Sciences
29 Sibirskiy trakt, Kazan, Russian Federation, 420029
Objective. Analysis of the frequency of occurrence of blood groups and phenotypes in patients with pancreatic cancer who received treatment in State Autonomous Healthcare Institution “Republican Clinical Oncological Dispensary of the Ministry of Healthcare of the Republic of Tatarstan” (RCOD) to establish a possible relation of these parameters to the disease.
Material and methods. The material for the study were the blood samples of patients admitted for treatment at RCOD with pancreatic cancer in 2015-2017. This work included the results of determination of blood groups using the ABO system, Rh factor, and phenotyping for the erythrocyte antigens C, C, E, E, Kell, and Cw, obtained in the clinical-diagnostic laboratory of RCOD. Sampling and processing of the obtained results was carried out using information systems “ALISa” and “MIS BARS”.
Results. During the specified period of 2015-2017, 570 patients with pancreatic cancer diagnosis were treated at RCOD. 69% of all cases occur in patients of 50 to 70 years old. In patients with pancreatic cancer, the A2 antigen was found in blood group A by 8.4% less frequently than in healthy people, and in blood group AB, on the contrary, by 4.2% more often in patients. Antigens C and E were detected in patients with pancreatic cancer more often by 3.8 and 9.3%, respectively. Kell antigen in these patients was twice as rare (4.1%) than among healthy patients (8.25%). In patients with pancreatic cancer, phenotypes with three dominant traits were more common and less common with a predominance of recessive antigenic traits. The results obtained can be used to identify people predisposed to pancreatic cancer, and determine the indications for screening.
Key words: pancreatic cancer, blood group (type), phenotyping of erythrocyte antigens.