I.R. Aglullin1,2, M.I. Aglullin1, I.A. Kamalov1, F.I. Didakunan1, S.E. Gabitova1
1Tatarstan Cancer Center, Kazan
2Kazan State Medical Academy ― Branch of the FSBEI FPE RMACPE MOH Russia, Kazan
Kamalov I.A. ― Cand. Med. Sc., oncologist of the Tatarstan Cancer Center
29 Sibirskiy Trakt, Kazan, Russian Federation, 420029, tel.: +7-917-267-55-11, (843) 519-27-03, e-mail: email@example.com
Aim ― study of the relationship between elevated mean platelet volume and survival of patients with rectal cancer.
Methods. The study included 146 patients with rectal cancer who underwent combined treatment (preoperative radiotherapy and surgical treatment). Were formed control group and main group. The groups were homogeneous by sex, age, localization, stages of malignant neoplasms and applied methods of surgical treatment. The main group included patients with an mean platelet volume of 10 femtoliters and more, and the control group included patients with an mean platelet volume of less than 10 femtoliters. Patients were observed for 5 years.
Results, discussion. Five-year survival in patients with rectal cancer with an increased mean platelet volume was 57%, and in patients with rectal cancer with normal mean platelet volume was 81%. In the group of patients with an increased mean platelet volume (main group), mortality was 43%, and in the group of patients with normal mean platelet volume (control group), the five-year mortality was 18%. Mortality associated with the progression of the malignant tumor of the rectum was significantly higher among patients with an elevated mean platelet volume. Platelets are multipurpose cells and are able to influence a wide range of pathophysiological events. In addition to its traditional role in hemostasis, platelets affect the multistage progression of the malignant tumor.
Conclusions. Metastatic progression and recurrence of a malignant tumor of the rectum in patients with an increased mean platelet volume is more common than in similar patients with normal mean platelet volume. An increased mean platelet volume in patients with malignant neoplasms of the rectum is a sign of a prognosis of poor survival.
Кеу words: mean platelet volume, rectal cancer, survival.