L.M. Nigmatullin1, I.G. Gataullin2,3, M.Yu. Ulyanin4,5, M.V. Burmistrov3-5

1AlmetyevskBranch of the Tatarstan Cancer Center, Clinic №3, Almetyevsk

2Tatarstan Cancer Center, Kazan

3Kazan State Medical Academy ― Branch of the FSBEI FPE RMACPE MOH Russia, Kazan

4Volga Region branch of N.N. Blokhin Russian Cancer Research Center, Kazan

5Republican Clinical Hospital, Kazan

Nigmatullin L.M. ― Oncologist of the Almetyevsk Branch of the Tatarstan Cancer Center, Clinic №3

30а Stroiteley Ave., Almetyevsk, Russian Federation, 423461, tel. +7-953-999-98-53, e-mail: lendrik777@rambler.ru


Purpose ― the improvement of the results of the organ-preserving therapy of non-muscle invasive cancer (NMIBC) and papillomatosis by the research and development of scientifically and methodologically based approach to photodynamic treatment.

Material and methods. 74 patients with new-onset papillomatosis, non-muscle invasive bladder cancer, recurrent NMIBC, who were under medical treatment from 2014 to 2016 in the Almetyevsk Branch of the Tatarstan Cancer Center, were included in the research.

The patients were divided into two groups. The main group included 14 people who are the carriers of human papilloma virus (HPV). The second group consisted of sixty people who had negative results for HPV.

All patients underwent standard treatment: transurethral resection (TUR) of the tumor of the urinary bladder + early intravesical chemotherapy (EIVCT). In the group with HPV positive status standard treatment was supplemented with photodynamic therapy (PDT).

Results. According to the research, we have found that there are 14 people (out of 74 with new-onset bladder cancer) who are positive for HVP. 8 of them are females (58%) and 6 are males (42%). The average age of those who have HPV is 48.50 years (m 12.45 years). In the group of those who are negative for HPV the average age is 64.28 years (m 10.24 years). Antiviral efficacy of PDT was evaluated on a base of diagnostic algorithm, including cystoscopy with repeated sextant biopsy and virologic examination. The observation time was 12 months. In the group of patients with HPV positive status in the postoperative period, when tested every 3 months, the HPV test was negative.

Conclusions. The findings of antiviral strength of photo chemotherapy are of utmost interest in relation to the investigating the causation of high-risk HPV in the bladder carcinogenesis.

Photo chemotherapy can be considered as the secondary prevention of recurrent bladder cancer for those patients who are positive for HPV and can be used as a compulsory adjuvant way of treatment in this case.

Key words: HPV, HPV and bladder cancer, photo chemotherapy, PDT.