D.P. Kovtun1,2, N.M. Anichkov2, O.G. Polushin1, E.V. Ponomaryeva1, G.N. Khrykov3
1City Clinical Oncology Center (56 Veteranov Ave. Saint Petersburg 198255 Russian Federation), 2North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
3Kirov Military Medical Academy, Saint-Petersburg
Kovtun D.P. ― pathologist of Pathology Department of City Clinical Oncology Center, postgraduate of the Department of pathology of North-Western State Medical University named after I.I. Mechnikov
56 Veteranov Ave., Saint Petersburg, Russian Federation, 198255, tel. +7-921-870-17-77, e-mail: damian85@mail.ru
Adstract. Literature review, uncovering modern aspects of pathologic diagnosis colorectal cancer ― third in relevance malignant neoplasms in the world. It is emphasized that in modern oncological clinics, the objects of the pathologist, during the processing of the biopsy and surgical material in such disease, were significantly expanded and become more complicated. Except histological analysis of tumor, pathologist has to accurately stage the disease through the pTNM system, to identify such prognostic criteria, as lymphovascular and perineural infestation, to evaluate the effect of neoadjuvant therapy and substantiate medical indications for further molecular-genetic research of material.
Key words: carcinoma of the colon and rectum, lymphovascular and perineural invasion, microsatellite instability.