R.R. Furina1,2, Ya.A. Furman1, S.A. Kazankova1, S.A. Kazankov1, E.A. Golodyuk1,2, M.O. Gremyakina1, N.N. Mitrakova1,2
1Republican Clinical Hospital, Yoshkar-Ola
2Volga State Technological University, Yoshkar-Ola
Mitrakova N.N. ― D. Med. Sc., Professor of the Department of Radio-Technical and Biomedical Systems of Volga State Technical University, Head of the Endoscopic Department of the Republican Clinical Hospital
33 Osipenko Str., Yoshkar-Ola, Russian Federation, 424030, tel.: (362) 42-64-54, +7-927-871-90-22, e-mail: endomitrakova@mail.ru
Abstract. The problem of the choice of informative signs of the urine volatile metabolites of patients as oncomarkers for the diagnosis of lung cancer is being solved. The chromatography-mass spectrograms obtained on chromatograph «Chromatech-Crystal-5000» determined the characteristics of about 150 metabolites isolated from urine of patients. Preliminary selection of 16 metabolites for further studies was performed. A two-stage mathematical analysis of chromatographic data was carried out. As information signs, the heights and peak areas of each metabolite were taken. At the first stage of the analysis, the validity of the null hypothesis for the sample data of the parameters and was verified. It is shown that only for the metabolite Disulfide dimethyl the null hypothesis is surely rejected. The second stage of the analysis of the parameters of this metabolite using the maximum likelihood method was used to estimate the probabilities of correct diagnosis of lung cancer for the control group and the group with lung cancer, respectively, equal to 0.733 and 0.677.
Кеу words: tumor markers, metabolites, lung cancer diagnosis.