S.Yu. Ilivanov, Yu.D. Ilivanov, E.F. Abdrakhmanov, M.Yu. Ulyanin, G.A. Usmanova, R.Sh. Khasanov
1Kazan State Medical Academy — Branch of the FSBEI FPE RMACPE MOH Russia, Kazan
2Tatarstan Cancer Center, Kazan
Ilivanov S.Yu. ― postgraduate student of the Department of Oncology, radiology and palliative medicine of the Kazan State Medical Academy — Branch of the FSBEI FPE RMACPE MOH Russia
36 Butlerov Str., Kazan, Russian Federation, 420012, tel. +7-967-473-17-84, e-mail: ilivanovs@mail.ru
Abstract. Renal cell carcinoma (RCC) is a common tumor disease, often diagnosed in advanced stages of the disease. Currently, the main methods of diagnosis are radiological methods, the study of tumor markers at the stage of diagnosis is not widely used.
The purpose of the study is the determination of diagnostic significance of ultrasound and computed tomography data with contrast enhancement, the level of tumor pyruvate kinase in serum.
Material аnd methods. 67 patients with a diagnosis «renal cancer», who received surgical treatment in Tatarstan Cancer Center were examined in 2017. All patients underwent an ultrasound examination of the kidneys, computed tomography of the abdominal cavity organs and retroperitoneal space with intravenous contrast (Trazograf 76% -20.0), study of plasma from the cubital vein on an empty stomach.
Results. The analysis using the Chi-square test showed when comparing the values between the norm, mean and high levels of Tu2MPK, no differences were observed. In this case, patients with a picture of a hypervascular neoplasm according to CT data have a high (38.1%) and an average (28.2%) level of tumor pyruvate kinase in the blood plasma. In other cases, a significant change in the level of Tu2MPk was not observed.
Conclusions. Interpretational patterns of ultrasound examination and computed tomography do not have statistically significant differences. The level of tumor pyruvate kinase is not reliably associated with the pattern of beam diagnostics. Determination of the level of tumor serum pyruvate kinase may improve the primary diagnosis of kidney cancer.
Key words: renal cell carcinoma, tumor pyruvate kinase, diagnostics, tumor marker, radiological diagnostics.