K.S. Korchagina1, S.V. Gamayunov1,2,4, L.A. Voropaeva1,2, N.M. Shahova3

1Republic Clinical Oncology Center, Cheboksary

2Chuvash State University named after I.N. Ulyanov, Cheboksary

3Federal Research Center the Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod

4Volga Federal Medical Research Center, Nizhny Novgorod

Korchagina K.S. ― pathomorphologist of the Republic Clinical Oncology Center

12-23 Titov Str., Jur’evec, Ivanovskaja oblast’, Russian Federation, 155450, tel. +7-937-378-80-23, e-mail:

Abstract. Photodynamic therapy (PDT) is a promising method for the treatment of tumors with a broad potential of clinical and research applications. However, there remain issues that need to be clarified. Among them are photosensitizer (PS) biodistribution in the tumor, photodynamic reactions which occur in human tumors, and morphological responses. Studying of the morphological response of human skin tumours after PDT with Chlorine E-6 photosensitizers is necessary for understanding mechanisms of PDT and developing new treatment strategies.

Key words: photodynamic therapy (PDT), Chlorine E-6 photosensitizers, morphological changes, vascular mechanisms of PDT.